Therapeutic applications of vitamin D analogues.
نویسندگان
چکیده
منابع مشابه
Therapeutic applications of vitamin D analogues.
In the sunnier parts of the world a dietary intake of vitamin D is unnecessary,* but for most of us it is a true vitamin. Its dihydroxylated metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2DO) is, however, a hormone synthesised in the kidney and borne by the bloodstream to distant target organs (gut, bone, and possibly the parathyroid glands) with a complex feedback mechanism regulating its rate ...
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This article is a short review of recent advances in structure-activity relationships and in design and synthesis of vitamin D analogues having various desirable biological activities, with emphasis on work in the author's laboratory.
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Secondary hyperparathyroidism (2HPT), a common disorder in patients with chronic renal failure, develops in response to phosphate retention and low serum 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3), calcitriol). Replacement therapy with calcitriol or its precursor 1alpha-hydroxyvitamin D(3) (1alphaOHD(3), alfacalcidol) often produces hypercalcaemia, especially when combined with calcium-based p...
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ژورنال
عنوان ژورنال: BMJ
سال: 1979
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.6195.888